IN SILICO ANALYSIS OF RESISTANCE GENE IDENTIFIERS ON PLASMIDS OF BLANDM-5 PRODUCING CARBAPENEM-RESISTANT ESCHERICHIA COLI STRAINS ISOLATED IN HUMANS AND ANIMALS

Due to their ability resist endpoint antimicrobials such as carbapenem, it is very important detect and monitor multi-drug resistant Gram negative strains with plasmids containing genes blaNDM-5 by new molecular methods. This study aimed perform in silico analysis of resistance gene identifiers on human animal-derived found open databases, which were analyzed whole genome sequencing techniques compare these genes. The plasmid genomic sequences 4 2 animal E. coli included our Silico using the Resistance Gene Identifier (RGI) option comprehensive antibiotic database default values. Human have different antimicrobial addition blaNDM-5. All at least 8 perfect matches. When all examined, 35 found. Besides blaNDM-5, mphA, qacEdelta1 sul1 plasmids. As a conclusion, was determined results that, regardless source, there may be besides We are opinion that routine surveillance studies should carried out considering one health approach Gram-negative pathogens coli, can contain cause isolated from sources.